Testosterone Shots Side Effects

low-testosterone-therapyWe all know that testosterone is a male hormone that is responsible for male sexuality, such as growth of facial hair and deep voice. What’s more, a lack of this hormone would cause a negative impact on the emotional and physical health in men and the symptoms can range from a low libido to depression. In this case, doctors may prescribe testosterone shots to give a boost. However, it is worth mentioning that these injections may cause side effects, especially when it has to be used for a long time in the treatment of infertility and blood disorders.

What is testosterone?

As a natural male hormone produced mainly by the testes, it plays an important role in maintaining the health of the male reproductive system. While a small amount of testosterone is also secreted by female’s ovaries and adrenal glands, it mainly regulates the reproductive organs and the development of secondary masculine characteristics seen in men. Since its levels naturally decline as men age, those over 65 are more likely to suffer from low testosterone levels. But it doesn’t necessarily mean that it won’t occur in boys. In fact, sometimes it is linked with delayed development in boys too.

Testosterone replacement therapy side effects in men

As mentioned in the beginning, testosterone injections, gels, patches, or pellets are often recommended to treat a decrease in this male hormone, which is characterized by low sexual drive, lack of morning wood, low sperm count, low energy levels, depression, difficulty concentrating, fatigue, irritability, and so on.

As one of the derivatives, testosterone undecanoate injection can promote male growth and development of secondary sexual characteristics, testicular and accessory sexual gland, promote protein synthesis, reduce catabolism, enhance immune function, promote bone growth, promote erythropoiesis, inhibit the secretion of gonadotropin in feedback way, and inhibit estrogen secretion. But it is better to warn you that this therapy has potential risks and may lead to some health problems as follows.

1. Virilization of females;
2. Water and sodium retention;
3. Polycythemia;
4. Nausea and vomiting;
5. Rashes;
6. Asthma;
7. Angioedema;
8. Abnormal liver function;
9. Increased HDL-C levels;
10. Euphoria;
11. Mood swings;
12. Propensity for violence;
13. Precocity and the early closure of epiphyseal plate of the long bones in children.


Although this therapy helps men with Low T, it is contraindicated in pregnant and lactating women and those with confirmed and suspected prostate cancer and breast cancer. In addition, it should be used with caution in the following cases as well.

1. Edema in patients with heart disease;
2. Prostate enlargement;
3. High blood pressure;
4. Epilepsy;
5. Trigeminal neuralgia;
6. Liver and kidney dysfunction
7. Children.

In general, 50 to 400 ml of testosterone shots every 2 to 4 weeks will be recommended by the doctor when a man’s testicles cannot produce enough this male hormone due to hypogonadism. Unlike the gel form, the injection one is cheaper and safer because topical formulations may lead to direct or indirect contact with children and cause serious complications. Mind you, this therapy should be used under the supervision of the physician since any negligence will result in mild to serious medical problems.

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